| Registro completo |
| Provedor de dados: |
Nature Precedings
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| País: |
United Kingdom
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| Título: |
A Study of the Mechanism of Action of Zervamicin IIB Peptide Antibiotic by Molecular Dynamics Simulation
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| Autores: |
Konstantin Shaitan
Olga V. Levtsova
Vladimir Makarov
Mikhail P. Kirpichnikov
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| Data: |
2009-08-16
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| Ano: |
2009
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| Palavras-chave: |
Pharmacology
Bioinformatics
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| Resumo: |
We model mechanism of action of a channel-forming peptide antibiotic, zervamicin IIB, by molecular dynamics (MD) simulation. Interaction of this peptide with neutral and negatively charged lipid bilayers is investigated. It is found that charge of membrane surface influences the orientation of zervamicin IIB molecule, that may in turn effect its permeation into the membrane. On this basis we propose modifications to ZrvIIB structure that may increase its affinity towards the prokaryotic cellular membrane. Zervamicin IIB transmembrane channels are modeled as bundles consisting of 4, 5 and 6 individual peptide monomers. Our results suggest that four monomers don’t form a stable water-filled ion channel. Thus the channel with the least number of monomers (and the lowest conductance level by literature data) is a pentamer.
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| Tipo: |
Manuscript
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| Identificador: |
http://precedings.nature.com/documents/3624/version/1
oai:nature.com:10101/npre.2009.3624.1
http://hdl.handle.net/10101/npre.2009.3624.1
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| Fonte: |
Nature Precedings
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| Direitos: |
Creative Commons Attribution 3.0 License
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